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Replication stress (RS) and chromosomal instability (CIN) are commonly observed features of cancer cells. RS has a destabilizing effect on the genome and, vice versa, whole chromosome aneuploidy as a result of CIN can induce a RS response. Our preliminary data analysis of cancer genomic data suggests a tendency of whole chromosome CIN (W-CIN) to co-occur with structural CIN (S-CIN), whilst S-CIN can also appear in numerical stable tumors. We also found a significant positive correlation of mRNA ...