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Submitter
Angela Wieland1
Programme
FOR28001
Creator
Angela Wieland1
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Investigation visible to you, out of a total of 1
Genomic instability is a hallmark of cancer and can be frequently induced by replication stress. Incomplete repair of replication intermediates can lead to persistent linkages between sister chromatides, detectable during mitosis as ultra-fine anaphase bridges (UFBs). The active resolution of UFBs via several UFB factors are crucial to prevent mitotic catastrophe, chromosomal missegregations or aneuploidy. Previous studies have already revealed that UFBs are processed by a distinct set of proteins, ...
Submitter: Angela Wieland
Studies: GFP/AID tagging of endogenous BLM for rapid protein depletion, Sister chromatid exchange assay of BLM depletable cell lines
Assays: No Assays
