Investigations

Replication stress is one of the major causes for chromosomal instability which is a hallmark of cancer. Incomplete repair can lead to severe mitotic defects and ultra-fine anaphase bridges (UFBs) are a typical consequence. So far, five different classes of UFBs have been discribed: fragile sites-UFBs, centromeric-UFBs, telomeric-UFBs, homologous recombination-UFBs and rDNA-UFBs, which can be distinguished by their location and the way how they arise. Although previous studies have already proposed ...

Genomic instability is a hallmark of cancer and can be frequently induced by replication stress. Incomplete repair of replication intermediates can lead to persistent linkages between sister chromatides, detectable during mitosis as ultra-fine anaphase bridges (UFBs). The active resolution of UFBs via several UFB factors are crucial to prevent mitotic catastrophe, chromosomal missegregations or aneuploidy. Previous studies have already revealed that UFBs are processed by a distinct set of proteins, ...