University of Applied Sciences Koblenz
Department: Not specified
ROR ID: Not specified
Web page: https://www.hs-koblenz.de/rac/index
Country: 
Germany
City: Koblenz
Address: Not specified
Related items
Projects: Test, SP-3: A statistical modeling approach to identify common triggers for replication stress and mitotic chromosome missegregation, SP-1: Deciphering signaling pathways that promote accurate chromosome segregation after replication stress, SP-2: Molecular mechanisms of replication stress-induced mitotic chromosome missegregation, SP9: Mutual impact of replication origin firing regulation and mitotic chromosome segregation
Institutions: University of Applied Sciences Koblenz, Institute of Molecular Biology, University of Göttingen University Medical Center (UMG) Institute of Molecular Oncology, Section for Cellular Oncology, University of Duisburg-Essen
https://orcid.org/0000-0003-3977-9982
Projects: Test, SP-3: A statistical modeling approach to identify common triggers for replication stress and mitotic chromosome missegregation, SP-1: Deciphering signaling pathways that promote accurate chromosome segregation after replication stress, SP-2: Molecular mechanisms of replication stress-induced mitotic chromosome missegregation, SP-4: Centrosome integrity as a determinant of replication stress and mitotic dysfunction, SP-5: Impaired chromosome integrity caused by mutations in members of the BTR complex, SP-8: The causes of replication stress in response to whole chromosomal aneuploidy, SP-Z: NGS-based approaches for systematic analysis of genomic and chromosome instability Bernd Wollnik, Göttingen, SP9: Mutual impact of replication origin firing regulation and mitotic chromosome segregation
Institutions: University of Applied Sciences Koblenz
Xiaoxiao Zhang is a Biomathematics and Bioinformatics PhD student in Maik Kschischo's group at the University of Applied Sciences Koblenz. She works in the FOR2800 research unit.
Our Research Unit addresses an important question on the origin of chromosome instability (CIN), which causes structural as well as numerical chromosome aberrations. Importantly, CIN and increased levels of chromosome aberrations are closely associated with many human diseases including cancer, neurodegenerative diseases and age-related syndromes and can act as key drivers for disease development and progression. An important condition that causes structural chromosome instability (S-CIN) leading ...
Projects: SP-3: A statistical modeling approach to identify common triggers for replication stress and mitotic chromosome missegregation, SP-1: Deciphering signaling pathways that promote accurate chromosome segregation after replication stress, SP-2: Molecular mechanisms of replication stress-induced mitotic chromosome missegregation, SP-4: Centrosome integrity as a determinant of replication stress and mitotic dysfunction, SP-5: Impaired chromosome integrity caused by mutations in members of the BTR complex, SP-6: Proteomics of mitotic inter sister chromatid junctions, SP-8: The causes of replication stress in response to whole chromosomal aneuploidy, SP-Z: NGS-based approaches for systematic analysis of genomic and chromosome instability Bernd Wollnik, Göttingen, SP9: Mutual impact of replication origin firing regulation and mitotic chromosome segregation
Web page: https://for2800.de/
Cancer is a disease of the genome, with both structural and numerical chromosomal aberrations, so called aneuploidy, occurring concomitantly in most tumors. Despite this co-occurrence, the advances in the characterization of point mutations and structural and numerical changes failed to provide an insight into a possible functional relationship between structural and whole chromosomal instability. Recently, novel evidence suggests that numerical chromosomal aberrations leads to delayed S phase ...
We intend to shed light on the interplay between the regulation of replication origin firing and mitotic chromosome segregation. The relationship between faithful genome replication and chromosome segregation is mutual: de-regulated genome replication causes replication stress and chromosome missegregation [1, 2]. Conversely, chromosome missegregation causes replication stress [3, 4]. Although it is clear that proper regulation of origin firing, the main focus of our lab, is key for complete and ...
Programme: FOR2800
Public web page: Not specified
To maintain genome stability, human cells depend on accurate DNA replication in S-phase and chromosome segregation in mitosis. Replication stress refers to slowing down or stalling of replication forks that occurs due to DNA lesions, R-loops or oncogene activation. One consequence of replication stress is entry of cells into mitosis with incompletely replicated DNA and thus aberrant mitosis. Phosphorylation of proteins by kinase ATR and its downstream effector CHK1 protects stalled replication ...
The objective of the central project is providing access to state-of-the-art sequencing technology and methods as well as novel next-generation sequencing (NGS)-based approaches to all partners and individual projects within the consortium. Advances in NGS and NGS-based approaches such as whole-genome sequencing (WGS) have tremendously improved the detection of structural variants/copy number variations (CNVs) and single somatic variants and mutations as measures of genome integrity. With ...
Genomic instability is a shared pathogenic mechanism of selected inherited, monogenic disorders caused by mutations in genes encoding proteins with important functions for genomic maintenance. Recent advances in next-generation sequencing (NGS) technologies have allowed the identification of novel genes associated with genomic instability syndromes. However, our understanding of alterations of genomic maintenance in mitotic cells and mechanisms of disease-associated chromosome instability is still ...
