University of Göttingen University Medical Center (UMG) Institute of Molecular Oncology, Section for Cellular Oncology
Department: Not specified
ROR ID: Not specified
Web page: http://www.moloncol.med.uni-goettingen.de/de/content/researchgroups/101.html
Country: 
Germany
City: Göttingen
Address:
Grisebachstrasse 8, 37077 Göttingen
Related items
Projects: Test, SP-3: A statistical modeling approach to identify common triggers for replication stress and mitotic chromosome missegregation, SP-1: Deciphering signaling pathways that promote accurate chromosome segregation after replication stress, SP-2: Molecular mechanisms of replication stress-induced mitotic chromosome missegregation, SP9: Mutual impact of replication origin firing regulation and mitotic chromosome segregation
Institutions: University of Applied Sciences Koblenz, Institute of Molecular Biology, University of Göttingen University Medical Center (UMG) Institute of Molecular Oncology, Section for Cellular Oncology, University of Duisburg-Essen
https://orcid.org/0000-0003-3977-9982
Our Research Unit addresses an important question on the origin of chromosome instability (CIN), which causes structural as well as numerical chromosome aberrations. Importantly, CIN and increased levels of chromosome aberrations are closely associated with many human diseases including cancer, neurodegenerative diseases and age-related syndromes and can act as key drivers for disease development and progression. An important condition that causes structural chromosome instability (S-CIN) leading ...
Projects: SP-3: A statistical modeling approach to identify common triggers for replication stress and mitotic chromosome missegregation, SP-1: Deciphering signaling pathways that promote accurate chromosome segregation after replication stress, SP-2: Molecular mechanisms of replication stress-induced mitotic chromosome missegregation, SP-4: Centrosome integrity as a determinant of replication stress and mitotic dysfunction, SP-5: Impaired chromosome integrity caused by mutations in members of the BTR complex, SP-6: Proteomics of mitotic inter sister chromatid junctions, SP-8: The causes of replication stress in response to whole chromosomal aneuploidy, SP-Z: NGS-based approaches for systematic analysis of genomic and chromosome instability Bernd Wollnik, Göttingen, SP9: Mutual impact of replication origin firing regulation and mitotic chromosome segregation
Web page: https://for2800.de/
Programme: This Project is not associated with a Programme
Public web page: Not specified
Structural and numerical chromosome aberrations are commonly and concomitantly detected in cancer and in age-related syndrome cells suggesting a functional relationship between structural and whole chromosome instability (S-CIN and W-CIN, respectively). Recent evidence suggests that replication stress can not only drive S-CIN and the generation of structural chromosome aberrations, but might also be involved in W-CIN leading to whole chromosome missegregation during mitosis resulting in aneuploidy. ...
Programme: FOR2800
Public web page: https://for2800.de/cases/sub-project-2-molecular-mechanisms-of-replication-stress-induced-mitotic-chromosome-missegregation/
Start date: 1st Jan 2019
