Maik Kschischo
SEEK ID: https://seek-for2800.de/people/4
Location:
Germany
ORCID:
https://orcid.org/0000-0003-3977-9982
Joined: 16th Jun 2021
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- SP-3: A statistical modeling approach to identify common triggers for replication stress and mitotic chromosome missegregation
- SP-1: Deciphering signaling pathways that promote accurate chromosome segregation after replication stress
- SP-2: Molecular mechanisms of replication stress-induced mitotic chromosome missegregation
- SP9: Mutual impact of replication origin firing regulation and mitotic chromosome segregation
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Our Research Unit addresses an important question on the origin of chromosome instability (CIN), which causes structural as well as numerical chromosome aberrations. Importantly, CIN and increased levels of chromosome aberrations are closely associated with many human diseases including cancer, neurodegenerative diseases and age-related syndromes and can act as key drivers for disease development and progression. An important condition that causes structural chromosome instability (S-CIN) leading ...
Projects: SP-3: A statistical modeling approach to identify common triggers for replication stress and mitotic chromosome missegregation, SP-1: Deciphering signaling pathways that promote accurate chromosome segregation after replication stress, SP-2: Molecular mechanisms of replication stress-induced mitotic chromosome missegregation, SP-4: Centrosome integrity as a determinant of replication stress and mitotic dysfunction, SP-5: Impaired chromosome integrity caused by mutations in members of the BTR complex, SP-6: Proteomics of mitotic inter sister chromatid junctions, SP-8: The causes of replication stress in response to whole chromosomal aneuploidy, SP-Z: NGS-based approaches for systematic analysis of genomic and chromosome instability Bernd Wollnik, Göttingen, SP9: Mutual impact of replication origin firing regulation and mitotic chromosome segregation
Web page: https://for2800.de/
We intend to shed light on the interplay between the regulation of replication origin firing and mitotic chromosome segregation. The relationship between faithful genome replication and chromosome segregation is mutual: de-regulated genome replication causes replication stress and chromosome missegregation [1, 2]. Conversely, chromosome missegregation causes replication stress [3, 4]. Although it is clear that proper regulation of origin firing, the main focus of our lab, is key for complete and ...
Programme: FOR2800
Public web page: Not specified
To maintain genome stability, human cells depend on accurate DNA replication in S-phase and chromosome segregation in mitosis. Replication stress refers to slowing down or stalling of replication forks that occurs due to DNA lesions, R-loops or oncogene activation. One consequence of replication stress is entry of cells into mitosis with incompletely replicated DNA and thus aberrant mitosis. Phosphorylation of proteins by kinase ATR and its downstream effector CHK1 protects stalled replication ...
Structural and numerical chromosome aberrations are commonly and concomitantly detected in cancer and in age-related syndrome cells suggesting a functional relationship between structural and whole chromosome instability (S-CIN and W-CIN, respectively). Recent evidence suggests that replication stress can not only drive S-CIN and the generation of structural chromosome aberrations, but might also be involved in W-CIN leading to whole chromosome missegregation during mitosis resulting in aneuploidy. ...
Programme: FOR2800
Public web page: https://for2800.de/cases/sub-project-2-molecular-mechanisms-of-replication-stress-induced-mitotic-chromosome-missegregation/
Start date: 1st Jan 2019
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Public web page: https://for2800.de/
Replication stress (RS) and chromosomal instability (CIN) are commonly observed features of cancer cells. RS has a destabilizing effect on the genome and, vice versa, whole chromosome aneuploidy as a result of CIN can induce a RS response. Our preliminary data analysis of cancer genomic data suggests a tendency of whole chromosome CIN (W-CIN) to co-occur with structural CIN (S-CIN), whilst S-CIN can also appear in numerical stable tumors. We also found a significant positive correlation of mRNA ...
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Country: Germany
City: Mainz
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Department: Not specified
Country: Germany
City: Koblenz
Web page: https://www.hs-koblenz.de/rac/index
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Department: Not specified
Country: Germany
City: Essen
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ROR ID: Not specified
Department: Not specified
Country: Germany
City: Göttingen
Web page: http://www.moloncol.med.uni-goettingen.de/de/content/researchgroups/101.html
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Creator: Maik Kschischo
Submitter: Maik Kschischo
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Creator: Maik Kschischo
Submitter: Maik Kschischo
Abstract (Expand)
Authors: X. Zhang, M. Kschischo
Date Published: 16th Dec 2021
Publication Type: Journal
Abstract (Expand)
Authors: N. K. Chunduri, P. Menges, X. Zhang, A. Wieland, V. L. Gotsmann, B. R. Mardin, C. Buccitelli, J. O. Korbel, F. Willmund, M. Kschischo, M. Raeschle, Z. Storchova
Date Published: 22nd Sep 2021
Publication Type: Journal
Abstract (Expand)
Authors: A. K. Schmidt, K. Pudelko, J. E. Boekenkamp, K. Berger, M. Kschischo, H. Bastians
Date Published: 11th Nov 2020
Publication Type: Journal
